Cdks set the replication schedule
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Cdks set the replication schedule
Cdks set the replication schedule T he cyclin-dependent kinases (Cdks) have an even bigger role in DNA replication than researchers thought, Thomson et al. reveal. The enzymes not only activate individual replication sites, they also control the large-scale pattern of DNA duplication by turning on clusters of replication forks known as replication factories. DNA replication sticks to a script. ...
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In eukaryotic cells, firing of DNA replication origins normally does not recur until after M phase. This characteristic is thought to be due to the properties of "initiation" proteins like Orc, Cdc6, and Mcms. Using formaldehyde cross-linking, we show that Cdc6p and Mcm7p associate specifically with replication origins during G1 but not during G2 in S. cerevisiae. Mcm7p's association with origi...
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Fungal cells exist in a diverse range of morphologies. Some species, such as Candida albicans, are dimorphic capable of growing either in a yeast-like form or as a hypha. Cyclin-dependent kinases (CDKs) have long been thought to play a central role in the yeast-hyphal decision. However, until recently direct links of CDKs with proteins that execute polarized growth were elusive. In this review ...
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JCB • VOLUME 178 • NUMBER 6 • 2007 892 For cdks, one is enough W e can’t turn sugars into a good pinot noir, but we do resemble yeast in one surprising way. Like the fungi, mammals require only one cyclin-dependent kinase (cdk) to complete the cell cycle, say David Santamaria, Mariano Barbacid (Spanish National Cancer Research Center, Madrid, Spain), and colleagues. Although yeast need only one...
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K umagai et al. describe how cy-clin-dependent kinases (Cdks) initiate DNA replication by promoting the interaction of two proteins conserved from yeast to mammals. In budding yeast, Cdks phosphorylate two replication origin proteins called Sld2 and Sld3, allowing them to bind a third protein called Dpb11. Together, these proteins recruit Cdc45, which then promotes the activation of the MCM hel...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2010
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1882iti1